This case study is the result of semi-structured interviews and email engagement with teaching and support staff involved in OER activities in the Facutly of Health Sciences (FHS) and for the OpenContent Directory (web portal) at UCT. The contributors (listed at the end of this study) gave their consent for the author to use their names and direct quotations, and their words are included here verbatim. The case study describes the FHS experience with OER, locating it within the UCT OER context and highlighting strategic priorities, perceived benefits, achievements, challenges, production processes, lessons learned, future plans, and advice for others interested in creating their own institutional OER initiatives.