Many of the restrictions on access to knowledge in Africa, but particularly in the Southern Africa Region, revolve around restrictive copyright practices and regulations, a lack of access to Internet-based technologies, out-dated paradigms for knowledge collection and dissemination, and the lack of creative and effective government supported enabling environments within higher education to match the vision of African leaders for knowledge and innovation in Africa in the 21st century. The report offers a series of recommendations to address these challenges, both at a policy level and with regard to research and dissemination (e.g. an ‘open knowledge platform’ for the region). These are of sufficient magnitude that a paradigm shift is required in thinking, knowledge generation and dissemination. Sufficient critical and concerted action will be necessary in order to produce a series of ‘break throughs’. Additional authors: Mark Burke, Eve Gray, Andrew Rens