Title: Week 9 - Unit 4_2: DNA Replication
Course: Biochemistry

Introduction

DNA replication is the synthesis of DNA , that occurs during the S phase of the interphase. The purpose of DNA replication is to create two daughter DNA molecules that are identical to the parental DNA. After the discovery of DNA's structure, researchers proposed three basic models for DNA replication: semi-conservative, conservative, and dispersive.

Expectation

This unit will discuss how the genetic information is transmitted from parents to progeny by replication of parental DNA. This process of replication is different in prokaryotes and Eukaryotes. DNA replication requires a number of proteins ; some participates as enzymes in the polymerization of nucleotide (DNA polymerase); others are responsible for unwinding the double-stranded DNA helix, holding it apart at the point of replication and preventing it from twisting. Maintaining the stability of the genome depends on a number of repair systems that correct occasional mistakes made during replication.

Course outline

1. Basic characteristics of DNA replication
2. Prokaryotic DNA replication
3. Eukaryotic DNA replication
4. DNA Repair

Learning outcomes

At the end of this unit, you should be able to:

1. Describe the mode of DNA replication
2. Explain the process of DNA replication in prokaryotes and eukaryotes
3. List main enzymes intervening in DNA replication process
4. Explain the function of telomeres in DNA replication
5. Describe the process of DNA mutation
6. Describe the different types of DNA repair